Moisturizers for Patients with Atopic Dermatitis: An Overview
نویسندگان
چکیده
Filaggrin is a structural protein that aggregate keratin filament and form cornified envelope which strengthen corneocytes. Also, filaggrin are degraded into natural moisturizing factor (NMF) which helps keeping stratum corneum hydrated and maintain acidic skin pH. The component of NMF is including sodium pyrrolidone carboxylic acid (PCA), urocanic acid, alanine, lactate and urea [2,3]. Mutations in filaggrin gene are identified in up to two-thirds of AD patients [4]. Additionally, Loss-of-function mutations in filaggrin gene are risk factors in developing this disease [5].
منابع مشابه
Moisturizers for patients with atopic dermatitis.
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with epidermal barrier defects which leads to dry skin that is easily disturbed by external exacerbating factors. It is now well established that moisturizers play an important role in preventing skin inflammation in AD, including reducing the amount of topical corticosteroid use. Thus, the use of moisturizers is currently rec...
متن کاملA review on the role of moisturizers for atopic dermatitis.
Effective management of atopic dermatitis (AD) involves the treatment of a defective skin barrier. Patients with AD are therefore advised to use moisturizers regularly. To date, there are few comparative studies involving moisturizers in patients with AD, and no classification system exists to objectively determine which types of moisturizers are best suited to specific AD phenotypes. With this...
متن کاملClinical Evaluation of Moisturizers with Physiological Analysis of Stratum Corneum TARC and TSLP
To verify the usefulness of moisturizers, a multi-center study was conducted on patients with atopic dermatitis who visited 3 university hospitals in Japan between November 2009 and March 2012. Thirty-seven patients with dry skin and stable symptoms who were receiving topical and oral treatments were given moisturizers for 8 weeks. The moisturizers contained components such as glycerin and seaw...
متن کاملCutaneous Leishmaniasis in Atopic Dermatitis Patients in Comparison with the Control Group in Kerman
Background: Atopic dermatitis is the most common chronic inflammatory dermatitis, due to immunological disorders. Patients with atopic dermatitis are prone to infectious diseases including bacterial infections. On the other hand, atopy may be protective against helminthes parasites. The objective of this study was to compare the frequency and clinical presentations of cutaneous leishmaniasis in...
متن کاملPerformance and Tolerability of the Moisturizers Cetaphil® and Excipial® in Atopic Dermatitis: What is the Evidence Based on Randomized Trials?
INTRODUCTION Moisturizers play a prominent role in the management of atopic dermatitis by improving the impaired skin barrier function and enhancing skin hydration. Their efficacy was evaluated in a recently published Cochrane Review 'Emollients and moisturizers for eczema'. OBJECTIVE In the present review, we summarize the performance and safety of Cetaphil® and Excipial® moisturizing produc...
متن کاملPrevalence of Atopic Eczema in Infants under Two Years Referring to the Vaccination Ward of the Hazrat Rasoul Akram Hospital, Tehran, Iran
Background & Aims: Atopic dermatitis is a common allergic disease recognized as a threat to public health. Atopic dermatitis is often observed in people with individual or family history of allergic diseases. Due to the importance of this disease and its early diagnosis, and the very limited number of studies on this topic, the current study was performed on the prevalence of atopic dermatitis ...
متن کامل